FACULTY

Co-Directors

D. Martin Watterson, Ph.D., m-watterson@northwestern.edu

Linda J. Van Eldik, Ph.D., vaneldik@northwestern.edu

Steering Committee

The Center is managed by a standing steering committee composed of faculty that represent diverse working interest subgroups. Interested individuals are encouraged to contact members of the steering committee.

Raymond Bergan,M.D., r-bergan@northwestern.edu

Alfonso Mondragon, Ph.D., a-mondragon@northwestern.edu

Karl Scheidt, Ph.D., scheidt@northwestern.edu

Richard Silverman, Ph.D., r-silverman@northwestern.edu

Mark Wainwright, M.D., Ph.D., m-wainwright@northwestern.edu

Faculty

Wayne Anderson, X-ray crystallographic analysis of protein-ligand interactions
wf-anderson@northwestern.edu

Raymond Bergan, Pharmacologic regulation of cell adhesion
r-bergan@northwestern.edu

Lester (Skip) Binder, Microtubule proteins, fibrillar pathology in neurodegenerative disease
l-binder@northwestern.edu

Vincent Cryns, Modulation of cell death pathways
v-cryns@northwestern.edu

John Disterhoft, Cellular mechanisms and pharmacological enhancement of learning in young and aging brain
jdisterhoft@northwestern.edu

Margarita Dubocovich, Molecular and cellular pharmacology of receptor signaling; neuromodulation of circadian thythms as a therapeutic target
mdubo@northwestern.edu

David Engman, Biology of parasitic diseases; Pathogenesis and treatment of myocarditis
Engman Laboratory
d-engman@northwestern.edu

Douglas Freymann, Structural basis of GTPase-ligand interactions
freymann@northwestern.edu

Jaime Grutzendler, Cellular dynamics in the neurovascular unit (neurons, astrocytes, microglia and blood vessels)
grutz@northwestern.edu
Lab website: http://grutzendlerlab.blogspot.com/

Adrian Gross, Structure and dynamics of ion channels
a-gross@northwestern.edu

Changiz Geula, Molecular neuropathology of Alzheimer's disease
c-geula@northwestern.edu

Sui Huang, The perinucleolar compartment and malignant transformation
s-huang2@northwestern.edu

William Karpus, Role of chemokines and cytokines in autoimmunity
Karpus Lab
w-karpus@northwestern.edu

Anthony Kossiakoff, Structure/function of hormone: receptor complexes; inhibitor-protease structural studies
koss@cummings.uchicago.edu

Mary Jo LaDu, Apolipoproteins and neurodegenerative disease
mladu@uic.edu

Richard Longnecker, Epstein-Barr virus transformation, latency and entry
Page
r-longnecker@northwestern.edu

Thomas Meade, Inorganic coordination chemistry; bioinorganic chemistry, and molecular imaging
tmeade@northwestern.edu

M-Marsel Mesulam, Cholinergic pathways, cognitive mapping, Alzheimer's disease
mmesulam@northwestern.edu

Richard Miller, Neural ion channels; neuronal death mechanisms
r-miller10@northwestern.edu

Stephen Miller, Regulation of T-cell immune responses, autorimmune disease models of multiple sclerosis
The Miller Lab
s-d-miller@northwestern.edu

Alfonso Mondragon, DNA topoisomerases & proteins that modify DNA topology; RNA structure/function, spectrin & related proteins
Mondragon Lab
a-mondragon@northwestern.edu

Ernest Moore, Ion channel biology and toxicology of cochlear hair cells
mooreer@northwestern.edu

Richard Morimoto, Molecular response to stress, protein folding quality control, misfolded proteins & neurodegenerative diseases
The Morimoto Laboratory
r-morimoto@northwestern.edu

Sonbinh Nguyen, Inorganic/organometaollic chemistry, organic synthesis, polymer science, environmental friendly catalysis and biomaterials
stn@northwestern.edu

Thomas O'Halloran, Chemistry and biology of transition metals and metalloproteins
The O'Halloran Group
t-ohalloran@northwestern.edu

Sarah Rice, Structural mechanisms for molecular motor function and regulation
s-rice@northwestern.edu

Steven Rosen, Hormonal therapies of cancer and resistance mechanisms
s-rosen@northwestern.edu

Karl Scheidt, New organic reaction development and the synthesis of molecules with interesting biological and structural attributes
The Scheidt Research Group
scheidt@northwestern.edu

Teepu Siddique, Molecular basis of neurodegeneration and amyotrophic lateral sclerosis
Neuromuscular Disorders Program
t-siddique@northwestern.edu

Richard Silverman, Design/synthesis of enzyme inhibitors; mechanisms of enzyme inactivation; enzyme-adduct structures
The Silverman Group
r-silverman@northwestern.edu

D. James Surmeier, Modulation of neuronal excitability
j-surmeier@northwestern.edu

Regan Thomson, Synthesis and application of natural products to medicinal and biological problems, especially cancer and neurodegenerative disorders
r-thomson@northwestern.edu

Linda Van Eldik, Brain inflammation, molecular glial biology, and neurodegenerative disorders
The Van Eldik Lab
vaneldik@northwestern.edu

Robert Vassar, Secretases and animal models of AlzheimerÕs disease
r-vassar@northwestern.edu

Mark Wainwright, Mechanisms of acute brain injury in children
m-wainwright@northwestern.edu

D. Martin Watterson, Signal transduction pathways as drug discovery targets
m-watterson@northwestern.edu

Phyllis Zee, Aging and the circadian clock system; genetics of sleep disorders
p-zee@northwestern.edu