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Prostate Biology
Brannigan, R. |
Lee, C.
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Robert E. Brannigan, MD
Department of Urology
M.D., Northwestern University
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Recent Publications:
Moreira SG Jr, Brannigan RE, Spitz A, Orejuela FJ, Lipshultz LI, Kim ED. Side effect profile of sildenafil citrate (ViagraȘ) in clinical practice. Urology. 56(3):474-6. 2000.
Gonzalez CM, Brannigan RE, Bervig T, Zelner D, Podlasek C, McKenna K, McVary KT. Protein and gene expression of nitric oxide isoforms I and III in the rat penile shaft. J Androl. 22(1):54-61. 2001.
Han M, Brannigan RE, Antenor JA, Roehl KA, Catalona WJ. Association of hemospermia with prostate cancer. J Urol. 2004 Dec;172(6, Part 1 of 2):2189-2192.
Brannigan RE. Ejaculatory disorders and lower urinary tract symptoms. Curr Urol Rep. 2004 Aug;5(4):280-6.
Jang TL, Blunt LW, Yap RL, Brannigan RE, Gonzalez CM. Large urethral diverticulum presenting as a scrotal mass: urethral reconstruction with ventral onlay buccal mucosa. J Urol. 2004 Jan;171(1):351-2.
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Chung Lee, Ph.D.
Department of Irology
Ph.D., West Virginia University
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My research has been in the area of prostatic physiology and cell biology. The prostate has
many unique properties which make it an interesting subject for scientific investigation.
For example, since the prostate is an androgen-sensitive tissue, maintenance of its
structural and functional integrity requires a constant support of androgen in the
circulation. Depletion of this androgenic support, as by castration in the host, would
result in drastic metabolic changes leading to programmed cell death and tissue
involution. In this regard, the prostate can be used to study the mechanism of androgen
action and the biology of programmed cell death. Furthermore, the prostate is also
susceptible to the development of abnormal growth, resulting in benign prostatic
hyperplasia and carcinoma of the prostate. Therefore, understanding the biology of
carcinogenesis and growth regulation in the prostate is an important health concern.
Finally, the prostate is a complex ductal system with branches and sub-branches extending
from one end to the other. The recent recognition of a regional variation in structural
and functional activity along the ductal system has made it possible for us to study the
various mechanisms that regulate the changing cellular activities in various regions of
the prostate. Again, this aspect of prostatic biology offers additional opportunity for
in-depth investigation in cellular and molecular biology. Currently, we are actively
pursuing the following subjects:
Characterization of prostatic ductal system as it relates to cellular proliferation, differentiation, and degeneration.
Characterization of the biological events associated with programmed cell death during the course of castration-induced prostatic involution.
Stromal and epithelial interaction in the prostate as it relates to cellular differentiation and proliferation and to the mechanism of androgen action.
Role of growth factors in mass growth of normal and malignant prostatic epithelial cells as it relates to therapy of prostatic cancer.
Recent Publications:
Zhang L, Shi J, Feng J, Klocker H, Lee C, Zhang J. Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer. 1: Prostate Cancer Prostatic Dis. 2004;7(4):327-32.
Pins MR, Fiadjoe JE, Korley F, Wong M, Rademaker AW, Jovanovic B, Yoo TK, Kozlowski JM, Raji A, Yang XJ, Lee C. Clusterin as a possible predictor for biochemical recurrence of prostate cancer following radical prostatectomy with intermediate Gleason scores: a preliminary report. Prostate Cancer Prostatic Dis. 2004;7(3):243-8.
Shim JH, Danielpour D, Lee C, Kim YS, Bahk YY, Yoo TK. Proteome profile changes during transdifferentiation of NRP-152 rat prostatic basal epithelial cells. Mol Cells. 2004 Feb 29;17(1):108-16.
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