Co-Directors

D. Martin Watterson, Ph.D., m-watterson@northwestern.edu

Linda J. Van Eldik, Ph.D., vaneldik@northwestern.edu

Steering Committee

The Center is managed by a standing steering committee composed of faculty that represent diverse working interest subgroups, such as Chemical Biology of the Brain, Neurodegenerative Disorders, Cancer Drug Discovery, Structural Biology, and Education Initiatives. Interested individuals are encouraged to contact members of the steering committee.

Raymond Bergan,M.D., r-bergan@northwestern.edu

Alfonso Mondragon, Ph.D., a-mondragon@northwestern.edu

Karl Scheidt, Ph.D., scheidt@northwestern.edu

Richard Silverman, Ph.D., r-silverman@northwestern.edu

Mark Wainwright, M.D., Ph.D., m-wainwright@northwestern.edu

Faculty

Wayne Anderson, X-ray crystallographic analysis of protein-ligand interactions
wf-anderson@northwestern.edu

Raymond Bergan, Pharmacologic regulation of cell adhesion
r-bergan@northwestern.edu

Lester (Skip) Binder, Microtubule proteins, fibrillar pathology in neurodegenerative disease
l-binder@northwestern.edu

Vincent Cryns, Modulation of cell death pathways
v-cryns@northwestern.edu

John Disterhoft, Cellular mechanisms and pharmacological enhancement of learning in young and aging brain
jdisterhoft@northwestern.edu

Margarita Dubocovich, Molecular and cellular pharmacology of receptor signaling; neuromodulation of circadian thythms as a therapeutic target
mdubo@northwestern.edu

David Engman, Biology of parasitic diseases; Pathogenesis and treatment of myocarditis
Engman Laboratory
d-engman@northwestern.edu

Douglas Freymann, Structural basis of GTPase-ligand interactions
freymann@northwestern.edu

Jaime Grutzendler, Cellular dynamics in the neurovascular unit (neurons, astrocytes, microglia and blood vessels)
grutz@northwestern.edu
Lab website: http://grutzendlerlab.blogspot.com/

Adrian Gross, Structure and dynamics of ion channels
a-gross@northwestern.edu

Changiz Geula, Molecular neuropathology of Alzheimer's disease
c-geula@northwestern.edu

Sui Huang, The perinucleolar compartment and malignant transformation
s-huang2@northwestern.edu

William Karpus, Role of chemokines and cytokines in autoimmunity
Karpus Lab
w-karpus@northwestern.edu

Anthony Kossiakoff, Structure/function of hormone: receptor complexes; inhibitor-protease structural studies
koss@cummings.uchicago.edu

Mary Jo LaDu, Apolipoproteins and neurodegenerative disease
mladu@uic.edu

Richard Longnecker, Epstein-Barr virus transformation, latency and entry
Page
r-longnecker@northwestern.edu

Thomas Meade, Inorganic coordination chemistry; bioinorganic chemistry, and molecular imaging
tmeade@northwestern.edu

M-Marsel Mesulam, Cholinergic pathways, cognitive mapping, Alzheimer's disease
mmesulam@northwestern.edu

Richard Miller, Neural ion channels; neuronal death mechanisms
r-miller10@northwestern.edu

Stephen Miller, Regulation of T-cell immune responses, autorimmune disease models of multiple sclerosis
The Miller Lab
s-d-miller@northwestern.edu

Alfonso Mondragon, DNA topoisomerases & proteins that modify DNA topology; RNA structure/function, spectrin & related proteins
Mondragon Lab
a-mondragon@northwestern.edu

Ernest Moore, Ion channel biology and toxicology of cochlear hair cells
mooreer@northwestern.edu

Richard Morimoto, Molecular response to stress, protein folding quality control, misfolded proteins & neurodegenerative diseases
The Morimoto Laboratory
r-morimoto@northwestern.edu

Sonbinh Nguyen, Inorganic/organometaollic chemistry, organic synthesis, polymer science, environmental friendly catalysis and biomaterials
stn@northwestern.edu

Thomas O'Halloran, Chemistry and biology of transition metals and metalloproteins
The O'Halloran Group
t-ohalloran@northwestern.edu

Sarah Rice, Structural mechanisms for molecular motor function and regulation
s-rice@northwestern.edu

Steven Rosen, Hormonal therapies of cancer and resistance mechanisms
s-rosen@northwestern.edu

Karl Scheidt, New organic reaction development and the synthesis of molecules with interesting biological and structural attributes
The Scheidt Research Group
scheidt@northwestern.edu

Teepu Siddique, Molecular basis of neurodegeneration and amyotrophic lateral sclerosis
Neuromuscular Disorders Program
t-siddique@northwestern.edu

Richard Silverman, Design/synthesis of enzyme inhibitors; mechanisms of enzyme inactivation; enzyme-adduct structures
The Silverman Group
r-silverman@northwestern.edu

D. James Surmeier, Modulation of neuronal excitability
j-surmeier@northwestern.edu

Regan Thomson, Synthesis and application of natural products to medicinal and biological problems, especially cancer and neurodegenerative disorders
r-thomson@northwestern.edu

Linda Van Eldik, Brain inflammation, molecular glial biology, and neurodegenerative disorders
The Van Eldik Lab
vaneldik@northwestern.edu

Robert Vassar, Secretases and animal models of AlzheimerÕs disease
r-vassar@northwestern.edu

Mark Wainwright, Mechanisms of acute brain injury in children
m-wainwright@northwestern.edu

D. Martin Watterson, Signal transduction pathways as drug discovery targets
m-watterson@northwestern.edu

Phyllis Zee, Aging and the circadian clock system; genetics of sleep disorders
p-zee@northwestern.edu